Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.71 |
| ▸ | RAB9A | P51151 | 13/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 7/20 | 0.71 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.71 |
| ▸ | RELA | Q04206 | 7/20 | 0.71 |
| ▸ | TP53 | P04637 | 4/20 | 0.71 |
| ▸ | HTT | P42858 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8516472 | 0.97 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9139676 | 0.83 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9138988 | 0.83 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL28715681 | 0.80 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL28708489 | 0.80 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL17744848 | 0.79 | PTGS1 (0.75) | NPC1RAB9ASMN1; SMN2TP53HTT | |
| SCHEMBL17744881 | 0.78 | FADS1 (0.72) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27600911 | 0.78 | FADS1 (0.52) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL20303198 | 0.76 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL1790434 | 0.76 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999052857-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1999-10-21 | — | — | WO | disclosed |