Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11497149 | 0.80 | — | — | |
| Glycine SCHEMBL4169207 | 0.75 | — | — | |
| Urea SCHEMBL27790776 | 0.73 | ALDH1A1 (0.36) | OR51E2HTTTSHRALDH1A1FGFR4 | |
| SCHEMBL3429197 | 0.73 | ABAT (0.40) | GLRA1SLC6A9OR51E2TSHRGABRR1 | |
| Acrylamide SCHEMBL1417837 | 0.72 | TSHR (0.65) | GLRA1SLC6A9OR51E2TSHRALDH1A1 | |
| Acrylamide SCHEMBL1908217 | 0.72 | TSHR (0.65) | GLRA1SLC6A9OR51E2TSHRALDH1A1 | |
| Glycine SCHEMBL7160926 | 0.72 | — | — | |
| Glycine SCHEMBL1148008 | 0.72 | — | — | |
| SCHEMBL45771 | 0.71 | — | — | |
| SCHEMBL6685557 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11005744-A | — | — | None | — | — | JP | disclosed |
| JP-H115744-A | AQUEOUS SOLUTION PREPARATION FOR EXTERNAL USE CONTAINING HYALURONIC ACID | TOA YAKUHIN KK | 1999-01-12 | — | — | JP | disclosed |