Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.65 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.59 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.59 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL1908217 | 1.00 | TSHR (0.65) | TSHRALDH1A1FGFR4GLRA1SLC6A9 | |
| Acrylamide SCHEMBL28362017 | 0.85 | ALDH1A1 (0.69) | TSHRALDH1A1FGFR4GLRA1SLC6A9 | |
| Acrylic Acid SCHEMBL27586368 | 0.85 | LMNA (0.62) | TSHRALDH1A1FGFR4GLRA1SLC6A9 | |
| Acrylamide SCHEMBL28209083 | 0.84 | TSHR (0.92) | TSHRALDH1A1FGFR4OR51E2LMNA | |
| Malonic Acid SCHEMBL2437426 | 0.82 | TSHR (0.65) | TSHRALDH1A1FGFR4GLRA1SLC6A9 | |
| Succinic Acid SCHEMBL28213422 | 0.82 | TSHR (0.65) | TSHRALDH1A1FGFR4OR51E2LMNA | |
| Succinic Acid SCHEMBL28443304 | 0.82 | TSHR (0.65) | TSHRALDH1A1FGFR4OR51E2LMNA | |
| Malonic Acid SCHEMBL27781561 | 0.82 | TSHR (0.65) | TSHRALDH1A1FGFR4GLRA1SLC6A9 | |
| Acrylamide SCHEMBL29083279 | 0.82 | ALDH1A1 (0.65) | TSHRALDH1A1FGFR4GLRA1SLC6A9 | |
| Acrylamide SCHEMBL28238685 | 0.82 | ALDH1A1 (0.65) | TSHRALDH1A1FGFR4GLRA1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296463-A1 | POLYMERS DERIVED FROM ITACONIC ACID | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2014-10-02 | — | — | US | claimed |
| CN-116018141-A | Salt and crystal form containing indole derivatives, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-109963979-A | The composition of organo-silicon compound containing beta-keto carbonyl group function | 瓦克化学股份公司 | 2019-07-02 | — | — | CN | disclosed |
| CN-106397646-B | High intensity supramolecular hydrogel and its preparation method and application | 天津大学 | 2018-06-15 | — | — | CN | disclosed |
| CN-106397646-A | High-strength super-molecular hydrogel, preparation method therefor and application of high-strength super-molecular hydrogel | 天津大学 | 2017-02-15 | — | — | CN | disclosed |
| CN-101448412-B | For composition and the method for surface modification of root vegetable products | MCCAIN FOODS LTD. (CA) | 2016-05-04 | — | — | CN | disclosed |
| US-20140296463-A1 | POLYMERS DERIVED FROM ITACONIC ACID | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2014-10-02 | — | — | US | disclosed |
| US-8557246-B2 | Fusion protein that directs vaccine antigens to antigen-presenting cells, and applications thereof | INSTITUTO NACIONAL DE INVESTIGACIÓN Y TECNOLOGÍA AGRARIA Y ALIMENTARIA (ES) | 2013-10-15 | — | — | US | disclosed |
| WO-2011082098-A1 | LYSINE AND ARGININE METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER | THE ROCKEFELLER UNIVERSITY (US) | 2011-07-07 | — | — | WO | disclosed |
| EP-2298910-A1 | FUSION PROTEIN THAT DIRECTS VACCINE ANTIGENS TO ANTIGEN-PRESENTING CELLS, AND APPLICATIONS THEREOF | Instituto Nacional De Investigación Y Tecnología Agraria Y Alimentaria (ES) | 2011-03-23 | — | — | EP | disclosed |
| US-20110061136-A1 | FUSION PROTEIN THAT DIRECTS VACCINE ANTIGENS TO ANTIGEN-PRESENTING CELLS, AND APPLICATIONS THEREOF | ALTERNATIVE GENE EXPRESSION, S.L. (ES) | 2011-03-10 | — | — | US | disclosed |
| CN-101970666-A | Fusion protein for directing vaccine antigen to antigen presenting cell and application thereof | INST NAC INVESTIGACION INIA | 2011-02-09 | — | — | CN | disclosed |
| WO-2010136182-A1 | METHYLGLYOXAL-SCAVENGING COMPOUNDS AND THEIR USE FOR THE PREVENTION AND TREATMENT OF PAIN AND/OR HYPERALGESIA | Ruprecht-Karls-Universität Heidelberg (DE) | 2010-12-02 | — | — | WO | disclosed |
| EP-2069386-A2 | SHARPLY RESOLVING LABELED PROTEIN MOLECULAR WEIGHT STANDARDS | Life Technologies Corporation (US) | 2009-06-17 | — | — | EP | disclosed |
| CN-101448412-A | Compositions and methods for surface modification of root vegetable products | MCCAIN FOODS LTD (CA) | 2009-06-03 | — | — | CN | disclosed |
| WO-2008042495-A2 | SHARPLY RESOLVING LABELED PROTEIN MOLECULAR WEIGHT STANDARDS | Life Technologies Corporation (US) | 2008-04-10 | — | — | WO | disclosed |
| EP-1218743-A2 | LAYERED DEVICE WITH CAPTURE REGIONS FOR CELLULAR ANALYSIS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001007915-A2 | LAYERED DEVICE WITH CAPTURE REGIONS FOR CELLULAR ANALYSIS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH (US) | 2001-02-01 | — | — | WO | disclosed |