SCHEMBL8516828

SCHEMBL8516828

N#Cc1ccc(CC=CF)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.48
CYP2A6 P11509 2/20 0.48
MAOB P27338 5/20 0.44
MAOA P21397 4/20 0.44
IDO1 P14902 2/20 0.43
HTT P42858 1/20 0.41
CYP19A1 P11511 2/20 0.40
KCNJ1 P48048 1/20 0.40
KCNH2 Q12809 1/20 0.40
ALDH1A1 P00352 1/20 0.38
CA12 O43570 1/20 0.38
CA2 P00918 1/20 0.38
CA3 P07451 1/20 0.38
CA6 P23280 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KIF11 P52732 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8516827 1.00 LOXL2 (0.48) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL9477517 0.94 KIF11 (0.45) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL9477506 0.94 KIF11 (0.45) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL28743584 0.79 LOXL2 (0.48) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL28224573 0.79 LOXL2 (0.48) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL17855518 0.78 LOXL2 (0.47) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL10671048 0.78 LOXL2 (0.47) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL7216910 0.78 LOXL2 (0.47) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL10671045 0.78 LOXL2 (0.47) LOXL2CYP2A6MAOBMAOAIDO1
SCHEMBL7216916 0.78 LOXL2 (0.47) LOXL2CYP2A6MAOBMAOAIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11236378-A None JP disclosed
JP-H11236378-A DICHIRAL PHENYLPYRIMIDINE DERIVATIVE AND ITS PRODUCTION INTERMEDIATE SAGAMI CHEM RES CENTER 1999-08-31 JP disclosed