Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 7/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800474 | 0.83 | NPSR1 (0.45) | NPSR1GAADRD2MEN1KMT2A | |
| SCHEMBL26954735 | 0.79 | NPSR1 (0.44) | NPSR1GAADRD2MEN1KMT2A | |
| SCHEMBL28323945 | 0.79 | EPHX2 (0.41) | NPSR1IDO1 | |
| SCHEMBL851496 | 0.79 | ROCK2 (0.59) | NPSR1 | |
| SCHEMBL2067960 | 0.79 | IDO1 (0.46) | GAAMEN1KMT2AIDO1CYP2C19 | |
| SCHEMBL26954805 | 0.78 | NPSR1 (0.43) | NPSR1GAADRD2MEN1KMT2A | |
| SCHEMBL4752129 | 0.77 | KDM4A (0.34) | POLBLMNAIDO1 | |
| SCHEMBL9449675 | 0.76 | GAA (0.44) | NPSR1GAADRD2MEN1KMT2A | |
| SCHEMBL26954826 | 0.76 | NPSR1 (0.43) | NPSR1GAADRD2MEN1KMT2A | |
| SCHEMBL12157315 | 0.75 | NPSR1 (0.57) | NPSR1GAAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134339-B1 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | ASTEX THERAPEUTICS LTD (GB) | 2014-09-17 | — | — | EP | disclosed |
| EP-2134339-B1 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | ASTEX THERAPEUTICS LTD (GB) | 2014-09-17 | — | — | EP | disclosed |
| US-8497294-B2 | Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases | ASTEX THERAPEUTICS LIMITED (GB) | 2013-07-30 | — | — | US | disclosed |
| US-8497294-B2 | Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases | ASTEX THERAPEUTICS LIMITED (GB) | 2013-07-30 | — | — | US | disclosed |
| US-8497294-B2 | Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases | ASTEX THERAPEUTICS LIMITED (GB) | 2013-07-30 | — | — | US | disclosed |
| EP-2433632-A1 | Compositions and combinations comprising non-racemic 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, for use in medicine | Astex Therapeutics Limited (GB) | 2012-03-28 | — | — | EP | disclosed |
| US-20110269808-A1 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2011-11-03 | — | — | US | disclosed |
| US-20110269808-A1 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2011-11-03 | — | — | US | disclosed |
| US-20100113551-A1 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2010-05-06 | — | — | US | disclosed |
| EP-2134339-A2 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | Astex Therapeutics Limited (GB) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008110846-A2 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113551-A1 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | MAP4K2, PRKCH, DSTYK | NPSR1 3044/4885GAA 4761/4885DRD2 3293/4885 |
| US-20110269808-A1 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | MAP4K2, MAP4K1, PRKCH | NPSR1 3259/4885GAA 4758/4885DRD2 3382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.