Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 5/20 | 0.37 |
| ▸ | ICMT | O60725 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659720 | 0.89 | CAMK2D (0.36) | CAMK2DGSK3BQPCTALDH1A1CYP1A2 | |
| SCHEMBL8365260 | 0.88 | CAMK2D (0.41) | CAMK2DICMTGSK3BQPCTRAB9A | |
| SCHEMBL8516843 | 0.88 | CAMK2D (0.49) | CAMK2DGSK3B | |
| SCHEMBL8516993 | 0.87 | CAMK2D (0.37) | CAMK2DGSK3BALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8362797 | 0.87 | PDE4B (0.43) | CAMK2DICMTGSK3BQPCTCA9 | |
| SCHEMBL8516330 | 0.87 | TP53 (0.42) | ICMTEDNRBTP53 | |
| SCHEMBL8516327 | 0.85 | CAMK2D (0.46) | CAMK2DGSK3B | |
| SCHEMBL8362233 | 0.84 | CAMK2D (0.38) | CAMK2DICMTLTB4R | |
| SCHEMBL7853098 | 0.84 | KDM4E (0.33) | GSK3BQPCTALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7654113 | 0.84 | KDM4E (0.33) | GSK3BQPCTALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999046260-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | claimed |
| WO-1999046260-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |