Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | QPCT | Q16769 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7815330 | 0.88 | MAPT (0.50) | ALDH1A1ASH1LMAPTCAMK2DTDP1 | |
| Acetic Acid SCHEMBL7815326 | 0.86 | MAPT (0.41) | ALDH1A1LMNAASH1LMAPTTDP1 | |
| Acetic Acid SCHEMBL8516618 | 0.86 | ASH1L (0.44) | ASH1LMAPTCAMK2DGSK3BQPCT | |
| Acetic Acid SCHEMBL7814686 | 0.86 | CAMK2D (0.48) | CAMK2DGSK3BRPS6KB1 | |
| Acetic Acid SCHEMBL7659096 | 0.85 | CAMK2D (0.40) | ASH1LMAPTCAMK2DGSK3BQPCT | |
| Acetic Acid SCHEMBL7663687 | 0.85 | MAPT (0.41) | ASH1LMAPTCAMK2DGSK3BQPCT | |
| Acetic Acid SCHEMBL8515954 | 0.84 | MAPT (0.39) | ASH1LMAPTCAMK2DGSK3BQPCT | |
| Acetic Acid SCHEMBL8366763 | 0.84 | MAPT (0.38) | ASH1LMAPTCAMK2DGSK3BQPCT | |
| Acetic Acid SCHEMBL7817159 | 0.83 | MAPT (0.37) | ALDH1A1LMNAASH1LMAPTTDP1 | |
| Acetic Acid SCHEMBL7657005 | 0.83 | MAPT (0.37) | ASH1LMAPTCAMK2DTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999046260-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |