Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 14/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | PRKACG | P22612 | 1/20 | 0.45 |
| ▸ | PRKACB | P22694 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7814679 | 0.88 | CAMK2D (0.46) | CAMK2DRPS6KB1PIM1PRKACAPRKACG | |
| Acetic Acid SCHEMBL7815395 | 0.87 | CAMK2D (0.51) | CAMK2DRPS6KB1PIM1PRKACAPRKACG | |
| Acetic Acid SCHEMBL8516677 | 0.86 | GSK3B (0.41) | CAMK2DRPS6KB1GSK3B | |
| Acetic Acid SCHEMBL8516995 | 0.86 | ALDH1A1 (0.38) | CAMK2DRPS6KB1GSK3B | |
| Acetic Acid SCHEMBL8516791 | 0.85 | CAMK2D (0.50) | CAMK2DRPS6KB1PIM1PRKACAPRKACG | |
| Acetic Acid SCHEMBL7657983 | 0.84 | CAMK2D (0.52) | CAMK2DRPS6KB1PIM1PRKACAPRKACG | |
| Acetic Acid SCHEMBL7815650 | 0.84 | CAMK2D (0.48) | CAMK2DRPS6KB1PIM1PRKACAPRKACG | |
| Acetic Acid SCHEMBL7817612 | 0.83 | CAMK2D (0.49) | CAMK2DRPS6KB1PIM1PRKACAPRKACG | |
| Acetic Acid SCHEMBL7665440 | 0.83 | CAMK2D (0.51) | CAMK2DRPS6KB1PIM1PRKACAPRKACG | |
| Acetic Acid SCHEMBL7807571 | 0.82 | CAMK2D (0.45) | CAMK2DRPS6KB1PIM1PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010025043-A1 | New pharmaceutical active compounds | ASTRA AKTIEBOLAG, A SWEDEN CORPORATION | 2001-09-27 | — | — | US | disclosed |
| US-6271231-B1 | Pharmaceutically active compounds | ASTRA AKTIEBOLAG (SE) | 2001-08-07 | — | — | US | disclosed |
| EP-0929551-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | Astra Aktiebolag (publ) (SE) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013368-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1998-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010025043-A1 | New pharmaceutical active compounds | CSNK1A1, CSNK1G1, CSNK2A1 | CAMK2D 338/4885RPS6KB1 267/4885PIM1 815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.