Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.41 |
| ▸ | F2 | P00734 | 5/20 | 0.41 |
| ▸ | F3 | P13726 | 2/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | SLC9A3 | P48764 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440642 | 0.94 | BCHE (0.41) | F10F2F3F7SLC9A3 | |
| SCHEMBL8374494 | 0.94 | BCHE (0.41) | F10F2F3F7SLC9A3 | |
| SCHEMBL8439128 | 0.82 | BCHE (0.41) | F10F2FFAR1BCHEACHE | |
| SCHEMBL8374887 | 0.82 | BCHE (0.41) | F10F2FFAR1BCHEACHE | |
| SCHEMBL8377548 | 0.80 | MAPT (0.37) | F10F2SLC9A3FFAR1BCHE | |
| SCHEMBL2565950 | 0.79 | AKR1C3 (0.53) | SLC9A3AKR1C3 | |
| SCHEMBL2565952 | 0.79 | AKR1C3 (0.53) | SLC9A3AKR1C3 | |
| SCHEMBL8439020 | 0.77 | FFAR1 (0.43) | F10F2F3F7FFAR1 | |
| SCHEMBL8373819 | 0.77 | FFAR1 (0.43) | F10F2F3F7FFAR1 | |
| SCHEMBL8442998 | 0.73 | FFAR1 (0.39) | F10F2F3F7FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883133-A | CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-16 | — | — | US | disclosed |