Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 3/20 | 0.48 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11483916 | 0.98 | SIGMAR1 (0.53) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| Iodide SCHEMBL10827372 | 0.98 | SIGMAR1 (0.53) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| Iodide SCHEMBL10827362 | 0.96 | SIGMAR1 (0.55) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8391999 | 0.96 | SIGMAR1 (0.50) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4211278 | 0.83 | SIGMAR1 (0.47) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9520387 | 0.83 | POLB (0.50) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8394942 | 0.82 | KDM4E (0.52) | SIGMAR1NOS1NOS3MEN1KMT2A | |
| Iodide SCHEMBL11164089 | 0.82 | POLB (0.49) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL10785309 | 0.82 | TAAR1 (0.55) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Iodide SCHEMBL11164087 | 0.82 | POLB (0.49) | SIGMAR1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| EP-0009362-B1 | HETEROCYCLIC DERIVATIVES OF GUANIDINE, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS COMPRISING THEM | McNeilab, Inc. (US) | 1984-06-27 | — | — | EP | disclosed |
| US-4414211-A | HYPOGLYCEMIC/- | MCNEILAB, INC. (US) | 1983-11-08 | — | — | US | disclosed |
| US-4345083-A | HYPOGLYCEMIC AGENTS | MCNEILAB, INC. (US) | 1982-08-17 | — | — | US | disclosed |
| US-4266062-A | HYPOGLYCEMIC ACTIVITY | MCNEILAB, INC. (US) | 1981-05-05 | — | — | US | disclosed |
| US-4211867-A | ANTISECRETORY AGENTS, HYPOGLYCEMIC AGENTS, ANTIARRHYTHMIA AGENTS | MCNEIL LABORATORIES, INCORPORATED (US) | 1980-07-08 | — | — | US | disclosed |
| EP-0009362-A1 | Heterocyclic derivatives of guanidine, their preparation and pharmaceutical formulations comprising them | McNeilab, Inc. (US) | 1980-04-02 | — | — | EP | disclosed |
| US-4182865-A | HYPOGLYCEMIC AGENTS | MCNEIL LABORATORIES, INC. (US) | 1980-01-08 | — | — | US | disclosed |