Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.45 |
| ▸ | HTR3B | O95264 | 3/20 | 0.45 |
| ▸ | HTR3A | P46098 | 3/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518311 | 0.83 | SIGMAR1 (0.54) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8391999 | 0.83 | SIGMAR1 (0.50) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4207962 | 0.83 | HTR3E (0.48) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL11483916 | 0.81 | SIGMAR1 (0.53) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| Iodide SCHEMBL10827372 | 0.81 | SIGMAR1 (0.53) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| Iodide SCHEMBL10827362 | 0.80 | SIGMAR1 (0.55) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9520387 | 0.79 | POLB (0.50) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| Iodide SCHEMBL11164089 | 0.77 | POLB (0.49) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL10785309 | 0.77 | TAAR1 (0.55) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Iodide SCHEMBL11164087 | 0.77 | POLB (0.49) | SIGMAR1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507672-B2 | Substituted pyrrolo[2,3-d]pyrimidines as LIM kinase 2 inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20090042893-A1 | KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2009-02-12 | — | — | US | disclosed |
| US-20040132115-A1 | Method for screening compounds for alpha1B adrenergic receptor antagonist and analgesic activity | FORD ANTHONY P D W (US) | 2004-07-08 | — | — | US | disclosed |
| US-6733982-B1 | FOR IDENTIFICATION OF ASSOCIATED LIGAND; SELECTIVE APLHA-1B-ADRENERGIC RECEPTOR ANTAGONISTS ARE USEFUL FOR PAIN RELIEF | SYNTEX (U.S.A.) LLC | 2004-05-11 | — | — | US | disclosed |
| US-6355641-B1 | HYPOTENSIVE AGENTS AND WOUND HEALING AGENTS | SYNTEX (U.S.A.) LLC | 2002-03-12 | — | — | US | disclosed |
| WO-2000055143-A1 | OXAZOLONE DERIVATIVES AND THEIR USE AS ALPHA-1 ADRENORECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042893-A1 | KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LIMK2, LIMK1, TNK2 | SIGMAR1 3077/4885HTR3E 3020/4885HTR3B 3184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.