Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 16/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 14/20 | 0.45 |
| ▸ | DRD4 | P21917 | 9/20 | 0.45 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7893196 | 0.99 | DRD3 (0.45) | DRD3FAAHDRD2DRD4HTR2A | |
| SCHEMBL8520327 | 0.95 | DRD3 (0.49) | DRD3FAAHDRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL7895543 | 0.94 | DRD3 (0.49) | DRD3FAAHDRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL8406541 | 0.88 | DRD2 (0.42) | DRD3DRD2DRD4HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL7896738 | 0.87 | IMPDH2 (0.42) | DRD3FAAHDRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL7896735 | 0.87 | IMPDH2 (0.42) | DRD3FAAHDRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL7892080 | 0.86 | POLB (0.47) | DRD3DRD2ADRA1A | |
| SCHEMBL7650118 | 0.86 | DRD2 (0.43) | DRD3DRD2DRD4HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL7893205 | 0.86 | MAPT (0.47) | DRD3DRD2DRD4HTR2AHTR1A | |
| SCHEMBL7885716 | 0.86 | MAPT (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923574-A1 | FUSED INDOLECARBOXAMIDES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998006717-A9 | FUSED INDOLECARBOXAMIDES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | — | 1998-07-23 | — | — | WO | disclosed |
| WO-1998006717-A1 | FUSED INDOLECARBOXAMIDES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |