Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST14 | Q9Y5Y6 | 12/20 | 0.51 |
| ▸ | F2 | P00734 | 10/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 9/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 9/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851813 | 0.93 | ST14 (0.53) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851057 | 0.91 | ST14 (0.60) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8509922 | 0.91 | ST14 (0.53) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851598 | 0.90 | ST14 (0.57) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851656 | 0.90 | ST14 (0.51) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL852305 | 0.89 | NPC1 (0.48) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851131 | 0.88 | ST14 (0.57) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8509724 | 0.88 | ST14 (0.49) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851281 | 0.87 | ST14 (0.62) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL852006 | 0.86 | F2 (0.53) | ST14F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | ST14 216/4885F2 112/4885PRSS1 3/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | ST14 216/4885F2 112/4885PRSS1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.