SCHEMBL8519375

SCHEMBL8519375

Cc1cccc(Oc2c[nH]c(=O)[nH]c2=O)c1C

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 1/20 0.46
MAPT P10636 1/20 0.39
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.38
KEAP1 Q14145 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31090687 0.79 DPYD (0.50) ATAD2MAPTALDH1A1LMNA
SCHEMBL29377898 0.75 MAPT (0.54) MAPTALDH1A1KEAP1
SCHEMBL1538371 0.75 MAPT (0.54) MAPTALDH1A1KEAP1
SCHEMBL3129822 0.74 LYN (0.50) ATAD2ALDH1A1LMNA
Formaldehyde SCHEMBL27667426 0.73 MAPT (0.53) MAPTALDH1A1LMNAKEAP1
SCHEMBL29128407 0.73 MEN1 (0.49) MAPTALDH1A1LMNA
SCHEMBL11614897 0.72 ATAD2 (0.50) ATAD2MAPTALDH1A1LMNA
SCHEMBL1748619 0.71 ALDH1A1 (0.50) ATAD2MAPTALDH1A1LMNA
SCHEMBL8486101 0.69 MEN1 (0.54) MAPTALDH1A1KEAP1
SCHEMBL11442900 0.69 MAPT (0.48) MAPTALDH1A1LMNAKEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912526-A1 ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Korea Research Institute of Chemical Technology (KR) 1999-05-06 EP claimed
WO-1997043266-A1 ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1997-11-20 WO claimed
EP-0912526-A1 ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Korea Research Institute of Chemical Technology (KR) 1999-05-06 EP disclosed
WO-1997043266-A1 ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1997-11-20 WO disclosed