Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.69 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.69 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.51 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.51 |
| ▸ | F7 | P08709 | 4/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.48 |
| ▸ | ITGAM | P11215 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388492 | 0.92 | ITGB3 (0.82) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| Hydrochloric Acid SCHEMBL8410378 | 0.84 | ITGB3 (0.50) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL8407980 | 0.82 | F10 (0.60) | ITGB3ITGA2BPRSS1ITGB2ITGAM | |
| SCHEMBL7347492 | 0.82 | ITGB3 (1.00) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL9335890 | 0.82 | ITGB3 (0.71) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL4426386 | 0.81 | F7 (0.64) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL27183437 | 0.81 | S1PR1 (0.57) | ITGB3ITGA2BS1PR1 | |
| SCHEMBL7390323 | 0.80 | ITGB3 (0.76) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7343876 | 0.80 | ITGB3 (0.67) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL9440340 | 0.80 | ITGB3 (0.67) | ITGB3ITGA2BF2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |