Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 10/20 | 0.91 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681184 | 0.96 | CASP1 (1.00) | CASP1SLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL5683299 | 0.86 | CASP1 (0.82) | CASP1SLC1A3SLC1A2SLC1A1TSHR | |
| SCHEMBL5680708 | 0.79 | CASP1 (0.75) | CASP1SLC1A3SLC1A2SLC1A1CASP3 | |
| SCHEMBL8410540 | 0.76 | CASP1 (0.59) | CASP1CAPN1CASP3 | |
| SCHEMBL8413237 | 0.75 | CASP1 (0.89) | CASP1SLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL5678920 | 0.75 | CASP1 (0.84) | CASP1 | |
| SCHEMBL5682798 | 0.75 | CASP1 (0.63) | CASP1 | |
| SCHEMBL5681328 | 0.75 | CASP1 (0.78) | CASP1CASP3 | |
| SCHEMBL8414183 | 0.75 | CASP1 (0.58) | CASP1CYP1A2TSHRALDH1A1HPGD | |
| SCHEMBL3909203 | 0.74 | CA1 (0.52) | CASP1CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932600-A2 | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1$g(b) CONVERTING ENZYME INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016504-A2 | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1β CONVERTING ENZYME INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |