SCHEMBL8520151

SCHEMBL8520151

C=CCn1c(C(F)(F)F)nc2ccc(Cl)cc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACSS2 Q9NR19 1/20 0.44
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
ALDH1A1 P00352 3/20 0.40
LMNA P02545 3/20 0.40
NPSR1 Q6W5P4 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
PAX8 Q06710 1/20 0.40
MAPT P10636 2/20 0.40
HPGD P15428 2/20 0.40
GAA P10253 2/20 0.39
TP53 P04637 1/20 0.39
PPARG P37231 1/20 0.39
HTT P42858 1/20 0.39
NCOA3 Q9Y6Q9 1/20 0.39
KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13676921 0.86 ACSS2 (0.47) ACSS2MEN1KMT2AALDH1A1LMNA
SCHEMBL8623725 0.83 KDM4E (0.50) ALDH1A1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL28437470 0.80 GAA (0.57) MEN1KMT2AALDH1A1LMNANPSR1
SCHEMBL13677300 0.76 GAA (0.47) ACSS2MEN1KMT2AALDH1A1LMNA
SCHEMBL13676920 0.75 KMT2A (0.45) MEN1KMT2AALDH1A1LMNANPSR1
SCHEMBL7873631 0.75 MEN1 (0.41) ACSS2MEN1KMT2AALDH1A1LMNA
SCHEMBL17378563 0.73 RAB9A (0.45) ACSS2MEN1KMT2AALDH1A1LMNA
SCHEMBL8695474 0.71 BRD4 (0.33) ALDH1A1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL7038026 0.69 HPGD (0.41) MEN1KMT2AALDH1A1LMNANPSR1
SCHEMBL13676923 0.68 ACSS2 (0.65) ACSS2CYP1A2CYP2C9CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0565121-B1 Silver halide photographic light-sensitive material FUJI PHOTO FILM CO LTD (JP) 1999-07-14 EP disclosed
US-5559240-A METHINE AND THIAZOLE DYES; STORAGE STABILITY; DISCOLORATION INHIBITION FUJI PHOTO FILM CO., LTD. (JP) 1996-09-24 US disclosed
US-5397693-A Methine dyes FUJI PHOTO FILM CO., LTD. (JP) 1995-03-14 US disclosed
EP-0565121-A1 Silver halide photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1993-10-13 EP disclosed