SCHEMBL8520458

SCHEMBL8520458

C=CCc1ccc(C(C)=NO)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
CYP3A4 P08684 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
TP53 P04637 1/20 0.46
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
ALOX12 P18054 1/20 0.46
XDH P47989 1/20 0.41
PPARG P37231 3/20 0.40
KDM4E B2RXH2 3/20 0.40
HPGD P15428 3/20 0.40
MAPT P10636 3/20 0.40
PPARD Q03181 2/20 0.40
GABRA1 P14867 2/20 0.40
GABRB2 P47870 2/20 0.40
MEN1 O00255 1/20 0.40
ALDH2 P05091 1/20 0.40
GAA P10253 1/20 0.40
AKR1B1 P15121 1/20 0.40
CNR1 P21554 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19917504 0.78 ALDH1A1 (0.50) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL5831132 0.78 ALDH1A1 (0.50) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL20529814 0.77 KDM1A (0.46) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL4564377 0.76 ALDH1A1 (0.48) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL195563 0.76 KMT2A (0.59) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL12360950 0.76 CA9 (0.52) ALDH1A1CYP3A4SMN1; SMN2KDM4EHPGD
SCHEMBL14298196 0.76 CA9 (0.52) ALDH1A1CYP3A4SMN1; SMN2KDM4EHPGD
SCHEMBL11500697 0.76 ALDH1A1 (0.40) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL19938067 0.75 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2PPARGKDM4EHPGD
SCHEMBL7873597 0.75 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2PPARGKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5879556-A Method of recovering extractant HENKEL CORPORATION 1999-03-09 US claimed
WO-1996022822-A1 METHOD OF RECOVERING EXTRACTANT HENKEL CORPORATION (US) 1996-08-01 WO claimed