Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 14/20 | 0.49 |
| ▸ | CASP3 | P42574 | 5/20 | 0.49 |
| ▸ | CASP9 | P55211 | 3/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | CASP4 | P49662 | 1/20 | 0.43 |
| ▸ | CASP5 | P51878 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381224 | 0.88 | CASP3 (0.53) | CASP1CASP3CASP9CASP7CTSB | |
| SCHEMBL8411108 | 0.88 | CASP1 (0.62) | CASP1CASP3CASP9CASP7 | |
| Naphthalene SCHEMBL8414904 | 0.87 | CASP1 (0.64) | CASP1CASP3CASP9CASP7CASP4 | |
| SCHEMBL8411381 | 0.87 | CASP3 (0.55) | CASP1CASP3CASP9CASP7CTSB | |
| Naphthalene SCHEMBL8411140 | 0.87 | CASP1 (0.57) | CASP1 | |
| SCHEMBL7888291 | 0.85 | CASP3 (0.54) | CASP1CASP3CASP9CASP7CTSB | |
| SCHEMBL20740990 | 0.85 | CASP3 (0.54) | CASP1CASP3CASP9CASP7CTSB | |
| SCHEMBL19015971 | 0.85 | CASP3 (0.54) | CASP1CASP3CASP9CASP7CTSB | |
| SCHEMBL20760042 | 0.84 | CASP3 (0.54) | CASP1CASP3CASP9CASP7CTSB | |
| SCHEMBL20760913 | 0.84 | CASP3 (0.54) | CASP1CASP3CASP9CASP7CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932598-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016502-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |