Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 8/20 | 0.80 |
| ▸ | RXRA | P19793 | 8/20 | 0.80 |
| ▸ | RARA | P10276 | 5/20 | 0.80 |
| ▸ | RARB | P10826 | 5/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038078 | 0.94 | PTGS2 (0.74) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL9038988 | 0.94 | PTGS2 (0.74) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL16034261 | 0.89 | RXRA (1.00) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL8112582 | 0.88 | PTGS2 (0.73) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL5215929 | 0.86 | PTGS2 (0.82) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL9049040 | 0.84 | PTGS2 (0.67) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL8925594 | 0.84 | RARG (0.60) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL8925277 | 0.84 | PTGS2 (0.79) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL8420247 | 0.84 | CYP2C9 (0.71) | RARGRXRARARARARBPTGS2 | |
| SCHEMBL9038810 | 0.84 | RARG (0.69) | RARGRXRARARARARBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |
| US-5434178-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G.D. SEARLE & CO. (US) | 1995-07-18 | — | — | US | disclosed |