Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 14/20 | 0.50 |
| ▸ | MAOB | P27338 | 14/20 | 0.50 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8520565 | 1.00 | MAOA (0.50) | MAOAMAOBSTSDRD2HTR1D | |
| SCHEMBL1513290 | 0.96 | MAOA (0.53) | MAOAMAOBSTSDRD2HTR1D | |
| SCHEMBL1513396 | 0.87 | MAOB (0.46) | MAOAMAOBSTSDRD2HTR1D | |
| SCHEMBL315565 | 0.86 | MAOB (0.55) | MAOAMAOB | |
| SCHEMBL1471642 | 0.83 | MAOB (0.55) | MAOAMAOBSTSHRH3 | |
| SCHEMBL4427945 | 0.81 | STS (0.59) | STSDRD2HTR1DDRD3 | |
| SCHEMBL21468547 | 0.79 | STS (0.62) | STSDRD2HTR1DDRD3HRH3 | |
| SCHEMBL3988527 | 0.79 | MAOB (0.64) | MAOAMAOB | |
| SCHEMBL14128769 | 0.79 | MAOA (0.53) | MAOAMAOBSTSCYP2A6HRH3 | |
| SCHEMBL5026108 | 0.78 | STS (0.64) | STSDRD2HTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931086-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998009977-A1 | TETRAHYDRONAPTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1998-03-12 | — | — | WO | disclosed |