Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 16/20 | 0.55 |
| ▸ | MAOA | P21397 | 15/20 | 0.55 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL315565 | 0.97 | MAOB (0.55) | MAOBMAOAPRKCIGRM5HSD17B1 | |
| SCHEMBL4157926 | 0.91 | MAOB (0.57) | MAOBMAOAGRM5HSD17B1HRH3 | |
| SCHEMBL3988527 | 0.89 | MAOB (0.64) | MAOBMAOAPRKCIHSD17B1 | |
| SCHEMBL1513290 | 0.87 | MAOA (0.53) | MAOBMAOASTSHRH3 | |
| SCHEMBL21468547 | 0.84 | STS (0.62) | STSHRH3 | |
| SCHEMBL8520565 | 0.83 | MAOA (0.50) | MAOBMAOASTSHRH3 | |
| SCHEMBL8520563 | 0.83 | MAOA (0.50) | MAOBMAOASTSHRH3 | |
| SCHEMBL5026108 | 0.82 | STS (0.64) | STS | |
| SCHEMBL17261615 | 0.81 | MAOB (0.58) | MAOBMAOAPRKCI | |
| SCHEMBL17332072 | 0.80 | MAOB (0.42) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368605-A1 | Novel Substituted 6,7-Dihydro-5H-Benzo[7]Annulene Compounds, Processes for their Preparation and Therapeutic Uses Thereof | SANOFI (FR) | 2025-12-04 | — | — | US | disclosed |
| US-20240150284-A1 | Novel Substituted 6,7-Dihydro-5H-Benzo[7]Annulene Compounds, Processes for their Preparation and Therapeutic Uses Thereof | SANOFI (FR) | 2024-05-09 | — | — | US | disclosed |
| WO-2024006776-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND MEDICAL USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |
| US-11713296-B2 | Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-l-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylate and preparation process thereof | SANOFI (FR) | 2023-08-01 | — | — | US | disclosed |
| US-11713296-B2 | Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-l-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylate and preparation process thereof | SANOFI (FR) | 2023-08-01 | — | — | US | disclosed |
| US-20220362248-A1 | COMBINATION COMPRISING PALBOCICLIB AND 6-(2,4-DICHLOROPHENYL)-5-[4-[(3S)-1-(3-FLUOROPROPYL)PYRROLIDIN-3-YL]OXYPHENYL]-8,9-DIHYDRO-7H-BENZO[7] ANNULENE-2-CARBOXYLIC ACID AND ITS USE FOR THE TREATMENT OF CANCER | SANOFI (FR) | 2022-11-17 | — | — | US | disclosed |
| US-20220073460-A1 | Novel Substituted 6,7-Dihydro-5H-Benzo[7]Annulene Compounds, Processes for their Preparation and Therapeutic Uses Thereof | SANOFI (FR) | 2022-03-10 | — | — | US | disclosed |
| US-11260057-B2 | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7] annulene-2-carboxylic acid and its use for the treatment of cancer | SANOFI (FR) | 2022-03-01 | — | — | US | disclosed |
| US-11214541-B2 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | SANOFI (FR) | 2022-01-04 | — | — | US | disclosed |
| US-11214541-B2 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | SANOFI (FR) | 2022-01-04 | — | — | US | disclosed |
| US-20170233340-A1 | NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2017-08-17 | — | — | US | disclosed |
| US-9714221-B1 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | SANOFI (FR) | 2017-07-25 | — | — | US | disclosed |
| US-9714221-B1 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | SANOFI (FR) | 2017-07-25 | — | — | US | disclosed |
| US-9714221-B1 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | SANOFI (FR) | 2017-07-25 | — | — | US | disclosed |
| US-7915315-B2 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915315-B2 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915315-B2 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-03-29 | — | — | US | disclosed |
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250368605-A1 | Novel Substituted 6,7-Dihydro-5H-Benzo[7]Annulene Compounds, Processes for their Preparation and Therapeutic Uses Thereof | CYP19A1, ESR1, ESR2 | MAOB 397/4885MAOA 421/4885PRKCI 4114/4885 |
| US-11214541-B2 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | CYP19A1, ESR1, GPER1 | MAOB 257/4885MAOA 266/4885PRKCI 3975/4885 |
| US-11260057-B2 | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7] annulene-2-carboxylic acid and its use for the treatment of cancer | CDK4, AURKB, ERBB2 | MAOB 2725/4885MAOA 4710/4885PRKCI 639/4885 |
| US-20240150284-A1 | Novel Substituted 6,7-Dihydro-5H-Benzo[7]Annulene Compounds, Processes for their Preparation and Therapeutic Uses Thereof | CYP19A1, ESR1, ESR2 | MAOB 416/4885MAOA 431/4885PRKCI 4296/4885 |
| US-11713296-B2 | Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-l-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylate and preparation process thereof | REN, AGTR1, AGT | MAOB 1349/4885MAOA 2002/4885PRKCI 4027/4885 |
| US-20220362248-A1 | COMBINATION COMPRISING PALBOCICLIB AND 6-(2,4-DICHLOROPHENYL)-5-[4-[(3S)-1-(3-FLUOROPROPYL)PYRROLIDIN-3-YL]OXYPHENYL]-8,9-DIHYDRO-7H-BENZO[7] ANNULENE-2-CARBOXYLIC ACID AND ITS USE FOR THE TREATMENT OF CANCER | CDK4, AURKB, ERBB2 | MAOB 2725/4885MAOA 4710/4885PRKCI 639/4885 |
| US-20220073460-A1 | Novel Substituted 6,7-Dihydro-5H-Benzo[7]Annulene Compounds, Processes for their Preparation and Therapeutic Uses Thereof | CYP19A1, ESR1, ESR2 | MAOB 397/4885MAOA 421/4885PRKCI 4114/4885 |
| US-20170233340-A1 | NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | CYP19A1, ESR1, ESR2 | MAOB 397/4885MAOA 421/4885PRKCI 4114/4885 |
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | S1PR1, S1PR4, S1PR2 | MAOB 4109/4885MAOA 4395/4885PRKCI 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.