Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852020 | 0.94 | BACE1 (0.51) | BACE1LMNATSHRALDH1A1KDM4E | |
| SCHEMBL852019 | 0.94 | BACE1 (0.51) | BACE1LMNATSHRALDH1A1KDM4E | |
| SCHEMBL30635255 | 0.84 | LMNA (0.57) | BACE1LMNATSHRALDH1A1KDM4E | |
| SCHEMBL121356 | 0.84 | LMNA (0.57) | BACE1LMNATSHRALDH1A1KDM4E | |
| Benzene SCHEMBL28217563 | 0.83 | TSHR (0.55) | BACE1LMNATSHRALDH1A1KDM4E | |
| SCHEMBL7659268 | 0.80 | BACE1 (0.52) | BACE1LMNATSHRALDH1A1KDM4E | |
| SCHEMBL69552 | 0.79 | BACE1 (0.60) | BACE1LMNATSHRALDH1A1KDM4E | |
| SCHEMBL69553 | 0.79 | BACE1 (0.60) | BACE1LMNATSHRALDH1A1KDM4E | |
| SCHEMBL852816 | 0.75 | KDM4E (0.46) | LMNAALDH1A1KDM4EHSD17B10ATM | |
| SCHEMBL852815 | 0.75 | KDM4E (0.46) | LMNAALDH1A1KDM4EHSD17B10ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |