Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Thifensulfuron-Methyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thifensulfuron-Methyl SCHEMBL2442597 | 0.93 | EDNRA (0.43) | PPARGPPARDPPARAEDNRAMAPT | |
| Thifensulfuron-Methyl SCHEMBL9139398 | 0.92 | EDNRA (0.46) | PPARGPPARDPPARAEDNRAMAPT | |
| Thifensulfuron-Methyl SCHEMBL29463414 | 0.92 | EDNRA (0.46) | PPARGPPARDPPARAEDNRAMAPT | |
| Thifensulfuron-Methyl SCHEMBL20723624 | 0.92 | EDNRA (0.46) | PPARGPPARDPPARAEDNRAMAPT | |
| Thifensulfuron-Methyl SCHEMBL53606 | 0.92 | EDNRA (0.46) | PPARGPPARDPPARAEDNRAMAPT | |
| Ammonia Solution, Strong SCHEMBL9536160 | 0.90 | EDNRA (0.42) | EDNRAMAPTMEN1KMT2A | |
| SCHEMBL65522 | 0.89 | EDNRA (0.43) | EDNRAMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL9715135 | 0.89 | EDNRA (0.43) | EDNRAMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL29397121 | 0.89 | EDNRA (0.43) | EDNRAMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL10754403 | 0.86 | EDNRA (0.47) | PPARGPPARDPPARAEDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944322-A1 | QUARTERNARY AMMONIUM SALTS AND THEIR USE IN AGRICULTURAL FORMULATIONS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998021963-A1 | QUARTERNARY AMMONIUM SALTS AND THEIR USE IN AGRICULTURAL FORMULATIONS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-05-28 | — | — | WO | disclosed |