Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | PLEC | Q15149 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13073879 | 0.91 | HDAC1 (0.57) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL22112765 | 0.83 | LMNA (0.51) | LMNAALDH1A1KDM4EMAPTHPGD | |
| Hydrochloric Acid SCHEMBL6852075 | 0.81 | LMNA (0.50) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL2014730 | 0.81 | LMNA (0.50) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL13074267 | 0.80 | HDAC2 (0.62) | HDAC2HDAC1HDAC3 | |
| SCHEMBL2018693 | 0.79 | LMNA (0.49) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL31708248 | 0.79 | LMNA (0.49) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL14341767 | 0.79 | CYP3A4 (0.63) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL29624972 | 0.79 | LMNA (0.53) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL1519088 | 0.79 | LMNA (0.49) | LMNAALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625195-B1 | THERAPY OF CENTRAL NERVOUS SYSTEM BY GENETICALLY MODIFIED CELLS | UNIV CALIFORNIA (US) | 1999-01-07 | — | — | EP | disclosed |
| US-5762926-A | Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-06-09 | — | — | US | disclosed |
| US-5650148-A | Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-22 | — | — | US | disclosed |
| EP-0625195-A1 | THERAPY OF CENTRAL NERVOUS SYSTEM BY GENETICALLY MODIFIED CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993010234-A1 | THERAPY OF CENTRAL NERVOUS SYSTEM BY GENETICALLY MODIFIED CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-05-27 | — | — | WO | disclosed |