Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596233 | 0.90 | CYP3A4 (0.59) | CYP3A4TP53LMNAMAPTNPC1 | |
| SCHEMBL8455922 | 0.85 | TP53 (0.50) | CYP3A4TP53LMNAMAPTTSHR | |
| SCHEMBL6595603 | 0.74 | CYP3A4 (0.42) | CYP3A4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6598863 | 0.74 | SMN1; SMN2 (0.47) | CYP3A4MAPTNPC1RAB9AGAA | |
| SCHEMBL6663261 | 0.74 | CYP3A4 (0.41) | CYP3A4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6663255 | 0.74 | CYP3A4 (0.41) | CYP3A4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6598880 | 0.73 | SMN1; SMN2 (0.41) | CYP3A4MAPTNPC1RAB9APOLB | |
| SCHEMBL6597798 | 0.73 | RAB9A (0.46) | CYP3A4LMNAMAPTTSHRRAB9A | |
| SCHEMBL8309448 | 0.71 | L3MBTL1 (0.49) | TP53LMNAMAPTNPC1RAB9A | |
| SCHEMBL6598654 | 0.71 | L3MBTL1 (0.46) | CYP3A4TP53NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888336-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997030989-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-28 | — | — | WO | disclosed |