Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | STS | P08842 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5245397 | 0.78 | CA2 (0.53) | CA2STSHTTMEN1ALDH1A1 | |
| SCHEMBL3585261 | 0.72 | CA2 (0.42) | CA2STSMEN1ALDH1A1MAPT | |
| SCHEMBL1156997 | 0.71 | POLB (0.46) | CA2HTTMEN1ALDH1A1MAPT | |
| SCHEMBL12917844 | 0.71 | STS (0.67) | CA2STSKMT2AHSD17B3CA1 | |
| SCHEMBL4765907 | 0.70 | CA2 (0.49) | CA2HTTMEN1MAPTKMT2A | |
| SCHEMBL6421620 | 0.70 | MAPK8 (0.48) | CA2STSMEN1ALDH1A1MAPT | |
| SCHEMBL8198869 | 0.70 | HTT (0.49) | CA2STSHTTMEN1ALDH1A1 | |
| SCHEMBL9388051 | 0.70 | CA2 (0.60) | CA2STSCA1FFAR1PLA2G2A | |
| SCHEMBL19876943 | 0.69 | POLB (0.47) | CA2HTTMEN1ALDH1A1MAPT | |
| SCHEMBL2745155 | 0.69 | HSD17B3 (0.50) | CA2HTTMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946552-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998013366-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-04-02 | — | — | WO | disclosed |