Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23531735 | 0.82 | PTK2 (0.36) | CA2PTK2ALDH1A1KMT2AMEN1 | |
| SCHEMBL1436752 | 0.82 | PTK2 (0.37) | CA2PTK2ALDH1A1KMT2AMEN1 | |
| SCHEMBL11723057 | 0.82 | MEN1 (0.43) | CA2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL334875 | 0.79 | PTK2 (0.38) | CA2PTK2ALDH1A1KMT2AMEN1 | |
| SCHEMBL10493783 | 0.79 | ALDH1A1 (0.38) | CA2PTK2ALDH1A1KMT2AMEN1 | |
| SCHEMBL1559973 | 0.76 | GSK3B (0.38) | CA2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL2200875 | 0.76 | CA1 (0.37) | CA2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL10370580 | 0.73 | CA2 (0.53) | CA2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL11053655 | 0.73 | STS (0.45) | CA2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3044354 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104031021-A | Method for preparing intermediate thiophene sulfonamide of brinzolamide | JINAN CHENGHUI SHUANGDA CHEMICAL CO LTD | 2014-09-10 | — | — | CN | claimed |
| US-20100009977-A1 | Process for the preparation of (R)-(+)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide. | USV LTD. (IN) | 2010-01-14 | — | — | US | claimed |
| EP-2079749-A2 | IMPROVED PROCESS FOR THE PREPARATION OF (R)-(+)-4-(ETHYIAMINO)-3,4-DIHYDRO-2-(3- METHOXYPROPYL)-2H-THIENO[3,2-E]-L,2-THIAZINE-6-SULFONAMIDE-L,L-DIOXIDE | USV LIMITED (IN) | 2009-07-22 | — | — | EP | claimed |
| WO-2008062463-A2 | IMPROVED PROCESS FOR THE PREPARATION OF (R)-(+)-4-(ETHYIAMINO)-3,4-DIHYDRO-2-(3- METHOXYPROPYL)-2H-THIENO[3,2-E]-L,2-THIAZINE-6-SULFONAMIDE-L,L-DIOXIDE | USV LIMITED (IN) | 2008-05-29 | — | — | WO | claimed |
| CN-104031021-A | Method for preparing intermediate thiophene sulfonamide of brinzolamide | JINAN CHENGHUI SHUANGDA CHEMICAL CO LTD | 2014-09-10 | — | — | CN | disclosed |
| US-8344136-B2 | Process for the preparation of brinzolamide | PHF S.A. (CH) | 2013-01-01 | — | — | US | disclosed |
| US-8344136-B2 | Process for the preparation of brinzolamide | PHF S.A. (CH) | 2013-01-01 | — | — | US | disclosed |
| US-20110118461-A1 | PROCESS FOR THE PREPARATION OF BRINZOLAMIDE | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2011-05-19 | — | — | US | disclosed |
| US-20110118461-A1 | PROCESS FOR THE PREPARATION OF BRINZOLAMIDE | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2011-05-19 | — | — | US | disclosed |
| US-20100317655-A1 | SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317655-A1 | SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317655-A1 | SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| WO-1996022099-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5538966-A | ENZYME INHIBITORS FOR TREATMENT OF GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-23 | — | — | US | disclosed |
| WO-1995019981-A1 | THIENOTHIAZINE SULFONAMIDE DERIVATIVES PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS CARBONIC ANHYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1995-07-27 | — | — | WO | disclosed |
| US-5378703-A | FOR CONTROLLING INTRAOCULAR PRESSURE | ALCON LABORATORIES, INC. (US) | 1995-01-03 | — | — | US | disclosed |
| US-5240923-A | Treating glaucoma | ALCON LABORATORIES, INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0527801-A1 | THIOPHENE SULFONAMIDES USEFUL AS CARBONIC ANYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| US-5153192-A | For controlling intraocular pressure | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| WO-1991015486-A1 | THIOPHENE SULFONAMIDES USEFUL AS CARBONIC ANYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1991-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009977-A1 | Process for the preparation of (R)-(+)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide. | SULT1E1, SULT1A1, SULT2A1 | CA2 1631/4885PTK2 3775/4885ALDH1A1 146/4885 |
| US-20100317655-A1 | SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE | CA2, CA9, CA1 | CA2 1/4885PTK2 4338/4885ALDH1A1 463/4885 |
| US-20110118461-A1 | PROCESS FOR THE PREPARATION OF BRINZOLAMIDE | CYP3A4, CYP4B1, SULT1E1 | CA2 1003/4885PTK2 4095/4885ALDH1A1 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.