Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGAV | P06756 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7485260 | 0.85 | ITGB1 (0.52) | ITGB1ITGA5ITGB3ITGAVITGB6 | |
| SCHEMBL13417768 | 0.76 | L3MBTL1 (0.61) | MAPTRAB9AL3MBTL1GAAKMT2A | |
| SCHEMBL7486591 | 0.75 | ITGB3 (0.49) | ITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL27680513 | 0.75 | BACE1 (0.43) | ITGB1ITGA5MAPTBACE1 | |
| SCHEMBL2557872 | 0.75 | GAA (0.68) | MAPTRAB9AL3MBTL1GAATDP1 | |
| SCHEMBL6805951 | 0.73 | ITGB1 (0.51) | ITGB1ITGA5ITGB3ITGAVITGB6 | |
| SCHEMBL7692410 | 0.72 | MAPT (0.64) | MAPTRAB9AL3MBTL1GAATDP1 | |
| Hydrochloric Acid SCHEMBL8356277 | 0.72 | NPC1 (0.51) | RAB9AL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL7796055 | 0.70 | ITGB1 (0.41) | ITGB1ITGA5MAPTRAB9AITGB3 | |
| SCHEMBL6643485 | 0.69 | ITGB1 (0.45) | ITGB1ITGA5MAPTRAB9AITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929120-A | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |