Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.46 |
| ▸ | TACR2 | P21452 | 5/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8522896 | 1.00 | TACR1 (0.46) | TACR1TACR2SIGMAR1OPRL1CTSS | |
| Hydrochloric Acid SCHEMBL8521973 | 0.94 | TACR1 (0.44) | TACR1TACR2SIGMAR1OPRL1GHSR | |
| SCHEMBL8522828 | 0.94 | TACR1 (0.44) | TACR1TACR2SIGMAR1OPRL1CTSS | |
| SCHEMBL8522826 | 0.94 | TACR1 (0.44) | TACR1TACR2SIGMAR1OPRL1CTSS | |
| Hydrochloric Acid SCHEMBL8521974 | 0.94 | TACR1 (0.44) | TACR1TACR2SIGMAR1OPRL1GHSR | |
| SCHEMBL8521896 | 0.93 | SIGMAR1 (0.46) | TACR1TACR2SIGMAR1OPRL1GHSR | |
| SCHEMBL8521895 | 0.93 | SIGMAR1 (0.46) | TACR1TACR2SIGMAR1OPRL1GHSR | |
| Hydrochloric Acid SCHEMBL8523055 | 0.85 | GHSR (0.51) | TACR1TACR2SIGMAR1OPRL1GHSR | |
| Hydrochloric Acid SCHEMBL8523052 | 0.85 | GHSR (0.51) | TACR1TACR2SIGMAR1OPRL1GHSR | |
| SCHEMBL8522337 | 0.82 | GHSR (0.40) | TACR1SIGMAR1CTSSCTSKGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |