SCHEMBL8523102

SCHEMBL8523102

CC1C(Oc2cccnc2)C2N(C)C(=O)CC[C@]2(C)[C@@H]2CC[C@]3(C)CCC[C@H]3[C@H]12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.34
CYP3A4 P08684 1/20 0.34
THRB P10828 1/20 0.34
TSHR P16473 1/20 0.34
THPO P40225 1/20 0.34
MEN1 O00255 1/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
CHRNB2 P17787 4/20 0.32
CHRNA4 P43681 4/20 0.32
GRIN1 Q05586 1/20 0.31
GRIN2B Q13224 1/20 0.31
CHRNB4 P30926 3/20 0.31
CHRNA3 P32297 3/20 0.31
CHRNA1 P02708 1/20 0.31
CHRNB1 P11230 1/20 0.31
CHRNA7 P36544 1/20 0.31
CHRNB3 Q05901 1/20 0.31
CYP19A1 P11511 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8524175 0.89 SRD5A1 (0.36) CYP19A1SRD5A1SRD5A2
SCHEMBL8523170 0.85 NAAA (0.31)
SCHEMBL8996733 0.85 STS (0.30) CYP19A1SRD5A1SRD5A2
SCHEMBL8523662 0.85 STS (0.30) CYP19A1SRD5A1SRD5A2
SCHEMBL8522916 0.85 CYP19A1 (0.30) GRIN1GRIN2BCYP19A1SRD5A1SRD5A2
SCHEMBL8524427 0.84 SRD5A1 (0.33) SRD5A1SRD5A2
SCHEMBL8522770 0.84 PLA2G7 (0.33) SRD5A1
SCHEMBL8523677 0.84 STS (0.32)
SCHEMBL8523449 0.84 SRD5A1 (0.33) SRD5A1
SCHEMBL8523238 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786999-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1999-01-20 EP claimed
EP-0786999-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-08-06 EP claimed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed
EP-0786999-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1999-01-20 EP disclosed
EP-0786999-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-08-06 EP disclosed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO disclosed