Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 5/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BCL9 | O00512 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646229 | 0.94 | ADRA1D (0.39) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL6784838 | 0.86 | ADRA1A (0.39) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL6715281 | 0.86 | BCL9 (0.35) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL6715274 | 0.86 | BCL9 (0.35) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL6216267 | 0.83 | PDE1C (0.38) | CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6194063 | 0.82 | CACNA1F (0.41) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL6196841 | 0.79 | MEN1 (0.35) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL7162576 | 0.77 | ADRA1D (0.54) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL6193641 | 0.77 | ADRA1D (0.54) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D | |
| SCHEMBL7978679 | 0.77 | PDE1C (0.39) | CACNA1FCACNA1DCACNA1SCACNA1CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0866708-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0866708-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-09-30 | — | — | EP | disclosed |
| WO-1997017969-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-22 | — | — | WO | disclosed |