Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST14 | Q9Y5Y6 | 9/20 | 0.61 |
| ▸ | F10 | P00742 | 8/20 | 0.61 |
| ▸ | F2 | P00734 | 7/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.55 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851827 | 0.89 | ST14 (0.75) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL851051 | 0.85 | ST14 (0.76) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL851279 | 0.82 | ST14 (0.78) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL851171 | 0.82 | F10 (0.76) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL851756 | 0.76 | F10 (0.79) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL850854 | 0.76 | ST14 (1.00) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL850827 | 0.74 | F10 (0.57) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL850652 | 0.74 | F10 (0.58) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL850881 | 0.73 | ST14 (0.73) | ST14F10F2PRSS1PRSS2 | |
| SCHEMBL851516 | 0.71 | ST14 (1.00) | ST14F10F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| US-20110082151-A1 | SULFONYLUREA MODULATORS OF ENDOTHELIN RECEPTOR | AUSPEX PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | ST14 216/4885F10 152/4885F2 112/4885 |
| US-20110082151-A1 | SULFONYLUREA MODULATORS OF ENDOTHELIN RECEPTOR | EDNRA, EDNRB, GLP1R | ST14 1574/4885F10 3438/4885F2 4442/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | ST14 216/4885F10 152/4885F2 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.