Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | CASP6 | P55212 | 2/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.61 |
| ▸ | CTSB | P07858 | 2/20 | 0.60 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | APEX1 | P27695 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 2/20 | 0.48 |
| ▸ | XPA | P23025 | 7/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985141 | 0.89 | MYC (0.54) | TDP1POLBL3MBTL1KDM4ECASP6 | |
| SCHEMBL19652479 | 0.73 | MEN1 (0.88) | TDP1POLBL3MBTL1KDM4EMEN1 | |
| SCHEMBL419818 | 0.72 | KLKB1 (0.60) | TDP1POLBKDM4ECTSBKLKB1 | |
| SCHEMBL447831 | 0.72 | KLKB1 (0.60) | TDP1POLBKDM4ECTSBKLKB1 | |
| SCHEMBL447832 | 0.72 | KLKB1 (0.60) | TDP1POLBKDM4ECTSBKLKB1 | |
| SCHEMBL13430836 | 0.70 | TDP1 (1.00) | TDP1POLBL3MBTL1KDM4ECASP6 | |
| SCHEMBL7985913 | 0.70 | KAT8 (0.55) | POLBL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL6731500 | 0.70 | AMY1A (0.55) | TDP1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL1787468 | 0.68 | L3MBTL1 (1.00) | TDP1POLBL3MBTL1KDM4ECASP6 | |
| SCHEMBL2757862 | 0.67 | KMT2A (0.65) | TDP1POLBL3MBTL1KDM4ECASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935957-A | PYRIDAZINE DERIVATIVES | VIROPHARMA INCORPORATED (US) | 1999-08-10 | — | — | US | disclosed |
| US-5821243-A | 3,4,5-TRIOXO-2H,3H,4H,5H-PYRIDAZINES; TRANSCRIPTASE INHIBITORS; NONTOXIC | VIROPHARMA INCORPORATED (US) | 1998-10-13 | — | — | US | disclosed |