Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 8/20 | 0.38 |
| ▸ | FNTB | P49356 | 8/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525212 | 0.90 | FNTA (0.39) | FNTAFNTBCYP11B1CYP11B2PGGT1B | |
| SCHEMBL8149667 | 0.82 | CYP11B1 (0.46) | FNTAFNTBCYP11B1CYP11B2PGGT1B | |
| SCHEMBL8523840 | 0.77 | MAPT (0.36) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL8142947 | 0.71 | CYP11B1 (0.47) | FNTAFNTBCYP11B1CYP11B2PGGT1B | |
| SCHEMBL8525208 | 0.65 | CYP11B1 (0.42) | FNTAFNTBCYP11B1CYP11B2PGGT1B | |
| SCHEMBL5891570 | 0.64 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL5891779 | 0.64 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL8525214 | 0.64 | CYP19A1 (0.55) | FNTAFNTBCYP11B1CYP11B2PGGT1B | |
| SCHEMBL5836533 | 0.64 | MAOB (0.66) | CYP19A1 | |
| SCHEMBL448443 | 0.62 | FNTA (0.54) | FNTAFNTBCYP11B1CYP11B2PGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939439-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-08-17 | — | — | US | claimed |
| US-5939439-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-08-17 | — | — | US | disclosed |