SCHEMBL8523867

SCHEMBL8523867

CC1C(Cc2cccnc2)C2N(C)C(=O)CC[C@]2(C)[C@@H]2CC[C@]3(C)CCC[C@H]3[C@H]12

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.35
KDM4E B2RXH2 3/20 0.34
CYP3A4 P08684 1/20 0.34
THRB P10828 1/20 0.34
TSHR P16473 1/20 0.34
THPO P40225 1/20 0.34
MEN1 O00255 1/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
LMNA P02545 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CYP19A1 P11511 2/20 0.32
CYP17A1 P05093 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
SRD5A1 P18405 1/20 0.32
POLB P06746 1/20 0.31
PKM P14618 1/20 0.30
RECQL P46063 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8996747 0.89 SRD5A1 (0.38) CYP19A1SRD5A1
SCHEMBL8996732 0.89 SRD5A1 (0.38) CYP19A1SRD5A1
SCHEMBL8524594 0.85 KDM4E (0.35) KDM4ECYP19A1SRD5A1
SCHEMBL8337551 0.84 SRD5A1 (0.33) CYP19A1SRD5A1
SCHEMBL8337553 0.84 SRD5A1 (0.33) CYP19A1SRD5A1
SCHEMBL8523102 0.81 KDM4E (0.34) KDM4ECYP3A4THRBTSHRTHPO
SCHEMBL8996737 0.79 SRD5A1 (0.38) CYP19A1SRD5A1
SCHEMBL8996741 0.79 SRD5A1 (0.38) CYP19A1SRD5A1
SCHEMBL8996766 0.76 SRD5A1 (0.36) CYP19A1SRD5A1
SCHEMBL8996758 0.76 SRD5A1 (0.36) CYP19A1SRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786999-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1999-01-20 EP claimed
EP-0786999-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-08-06 EP claimed
EP-0724592-A1 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS MERCK & CO. INC. (US) 1996-08-07 EP claimed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed
WO-1995011254-A1 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS MERCK & CO., INC. (US) 1995-04-27 WO claimed
EP-0724592-A1 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS MERCK & CO. INC. (US) 1996-08-07 EP disclosed
WO-1995011254-A1 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS MERCK & CO., INC. (US) 1995-04-27 WO disclosed