Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 11/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.38 |
| ▸ | HSD17B7 | P56937 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996737 | 1.00 | SRD5A1 (0.38) | SRD5A1SRD5A2HSD17B7CYP19A1 | |
| SCHEMBL8996740 | 0.92 | HSD17B7 (0.39) | SRD5A1SRD5A2HSD17B7 | |
| SCHEMBL8996721 | 0.84 | SRD5A1 (0.34) | SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL8996714 | 0.84 | SRD5A1 (0.34) | SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL8996742 | 0.83 | SRD5A1 (0.34) | SRD5A1SRD5A2HSD17B7 | |
| SCHEMBL8996745 | 0.83 | SRD5A1 (0.34) | SRD5A1SRD5A2HSD17B7 | |
| SCHEMBL8996732 | 0.83 | SRD5A1 (0.38) | SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL8996747 | 0.83 | SRD5A1 (0.38) | SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL8996707 | 0.82 | SRD5A1 (0.33) | SRD5A1SRD5A2HSD17B7 | |
| SCHEMBL8523198 | 0.82 | SRD5A1 (0.34) | SRD5A1SRD5A2HSD17B7CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724592-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO. INC. (US) | 1996-08-07 | — | — | EP | claimed |
| WO-1995011254-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO., INC. (US) | 1995-04-27 | — | — | WO | claimed |
| EP-0724592-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO. INC. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011254-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO., INC. (US) | 1995-04-27 | — | — | WO | disclosed |