Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 14/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 14/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 2/20 | 0.43 |
| ▸ | FNTB | P49356 | 2/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142947 | 0.90 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL8523927 | 0.82 | FNTA (0.38) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL446009 | 0.81 | CYP11B1 (0.55) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL8151367 | 0.76 | CYP11B1 (0.44) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL6981310 | 0.73 | HSP90AA1 (0.42) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL85902 | 0.71 | HTR1A (0.46) | CYP11B2CYP19A1 | |
| SCHEMBL5891570 | 0.71 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL5891779 | 0.71 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL6316290 | 0.71 | CYP11B1 (0.48) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL8525212 | 0.71 | FNTA (0.39) | CYP11B1CYP11B2CYP19A1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | claimed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | claimed |
| US-6077853-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |