Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.44 |
| ▸ | LDLR | P01130 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593693 | 0.86 | MAPK14 (0.81) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL4584430 | 0.78 | MAPK14 (0.51) | MAPK14PIK3CGPIK3CACCNA2CDK2 | |
| SCHEMBL8483981 | 0.78 | MAPK14 (0.73) | MAPK14PIK3CGPIK3CABRD4BRDT | |
| SCHEMBL8485273 | 0.77 | MAPK14 (0.59) | MAPK14PIK3CGPIK3CABRD4BRDT | |
| SCHEMBL6962991 | 0.77 | MAPK14 (0.64) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6957344 | 0.74 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL8524328 | 0.73 | MAPK14 (0.44) | MAPK14EGFR | |
| SCHEMBL8019885 | 0.69 | PIK3CG (0.52) | MAPK14PIK3CGPIK3CACDK2PIK3CB | |
| SCHEMBL27441160 | 0.67 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL8860318 | 0.66 | MAPK14 (0.49) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869660-A | Process of preparing imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| US-5739143-A | Imidazole compounds and compositions | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-14 | — | — | US | disclosed |