Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975496 | 0.79 | MAPK14 (0.43) | MAPK14MAPK11MAP4K4EGFRFRK | |
| SCHEMBL8524327 | 0.73 | MAPK14 (0.59) | MAPK14EGFR | |
| SCHEMBL4593693 | 0.73 | MAPK14 (0.81) | MAPK14 | |
| SCHEMBL4584430 | 0.70 | MAPK14 (0.51) | MAPK14MAPK11EGFRCSNK1A1KCNH2 | |
| SCHEMBL4601390 | 0.64 | MAPK14 (0.43) | MAPK14MAPK11MAP4K4EGFRFRK | |
| SCHEMBL1639908 | 0.64 | MAPK14 (0.50) | MAPK14MAPK11MAP4K4MAPK9CSNK1A1 | |
| SCHEMBL4835277 | 0.63 | — | — | |
| SCHEMBL6962991 | 0.62 | MAPK14 (0.64) | MAPK14 | |
| SCHEMBL1640808 | 0.62 | CSNK1D (0.45) | MAPK14MAP4K4EGFRFRKMAPK9 | |
| SCHEMBL8418263 | 0.62 | MAPK14 (0.53) | MAPK14MAPK11MAP4K4MAPK9CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869660-A | Process of preparing imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| US-5739143-A | Imidazole compounds and compositions | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-14 | — | — | US | disclosed |