SCHEMBL8524718

SCHEMBL8524718

O=Cc1ccc(C(=O)O)c(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 3/20 0.66
▸ L3MBTL1 Q9Y468 1/20 0.66
▸ DNASE1L3 Q13609 1/20 0.61
▸ PRMT1 Q99873 1/20 0.61
▸ MEN1 O00255 2/20 0.60
▸ POLB P06746 2/20 0.60
▸ KMT2A Q03164 2/20 0.60
▸ ALPL P05186 1/20 0.60
▸ ALPI P09923 1/20 0.60
▸ ALPG P10696 1/20 0.60
▸ ATM Q13315 1/20 0.58
▸ PLEC Q15149 1/20 0.58
▸ CA9 Q16790 13/20 0.51
▸ CA1 P00915 11/20 0.51
▸ CA2 P00918 11/20 0.51
▸ CA12 O43570 4/20 0.49
▸ CA14 Q9ULX7 3/20 0.47
▸ CA7 P43166 2/20 0.46
▸ ALB P02768 1/20 0.45
▸ CDC25A P30304 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14393164 0.93 USP2 (0.73) USP2L3MBTL1DNASE1L3PRMT1MEN1
6-Carboxyfluorescein SCHEMBL9906208 0.86 USP2 (0.69) USP2L3MBTL1DNASE1L3PRMT1MEN1
6-Carboxyfluorescein SCHEMBL29369299 0.86 USP2 (0.69) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL12045940 0.85 USP2 (0.68) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL13384808 0.85 USP2 (0.85) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL12458517 0.85 USP2 (0.58) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL19886589 0.85 USP2 (0.62) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL14148863 0.84 USP2 (0.60) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL20254033 0.84 USP2 (0.77) USP2L3MBTL1DNASE1L3PRMT1MEN1
SCHEMBL107875 0.83 USP2 (0.76) USP2L3MBTL1DNASE1L3PRMT1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220220314-A1 POLYMERIC DYES WITH LINKER GROUPS COMPRISING DEOXYRIBOSE Sony Group Corporation (JP) 2022-07-14 — — US disclosed
EP-3283499-B1 DUAL QUENCHER PROBES BIOSEARCH TECH INC (US) 2022-07-06 — — EP disclosed
EP-3670523-B1 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND THEIR USE IN METHODS FOR NUCLEIC ACID SEQUENCING AGILENT TECHNOLOGIES INC (US) 2021-08-11 — — EP disclosed
US-20210040145-A1 MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) 2021-02-11 — — US disclosed
US-10745437-B2 Means and methods for site-specific functionalization of polypeptides LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2020-08-18 — — US disclosed
US-8766238-B2 Polymeric anions/cations MERCK PATENT GMBH (DE) 2014-07-01 — — US disclosed
EP-2455457-A2 Covalent tethering of functional groups to proteins PROMEGA CORPORATION (US) 2012-05-23 — — EP disclosed
EP-2369006-A1 Covalent tethering of functional groups to proteins Promega Corporation (US) 2011-09-28 — — EP disclosed
US-7550582-B2 labeled Peptide Nucleic Acid (PNA) derivatives which carry one or more phosphoryl radicals at the N terminus of the PNA backbone for fluorescence in-situ hybridization (FISH) detection; can be purified using chromatography or electrophoresis; use as pharmaceuticals and diagnostic agents SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-06-23 — — US disclosed
US-20080070258-A1 labeled Peptide Nucleic Acid (PNA) derivatives which carry one or more phosphoryl radicals at the N terminus of the PNA backbone for fluorescence in-situ hybridization (FISH) detection; can be purified using chromatography or electrophoresis; use as pharmaceuticals and diagnostic agents AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2008-03-20 — — US disclosed
US-7217531-B2 Multiplex analysis using membrane-bound sensitizers MONOGRAM BIOSCIENCES (US) 2007-05-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220220314-A1 POLYMERIC DYES WITH LINKER GROUPS COMPRISING DEOXYRIBOSE H1-0, POLM, H1-2 USP2 3575/4885L3MBTL1 7/4885DNASE1L3 123/4885
US-20210040145-A1 MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES PTMS, DNPEP, LNPEP USP2 1380/4885L3MBTL1 630/4885DNASE1L3 2391/4885
US-10745437-B2 Means and methods for site-specific functionalization of polypeptides PTMS, DNPEP, LNPEP USP2 1380/4885L3MBTL1 630/4885DNASE1L3 2391/4885
US-20080070258-A1 labeled Peptide Nucleic Acid (PNA) derivatives which carry one or more phosphoryl radicals at the N terminus of the PNA backbone for fluorescence in-situ hybridization (FISH) detection; can be purified using chromatography or electrophoresis; use as pharmaceuticals and diagnostic agents NPPA, PNKP, PHAX USP2 4870/4885L3MBTL1 2662/4885DNASE1L3 128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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