Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 7/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452615 | 0.82 | HDAC6 (0.50) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL8524867 | 0.80 | EGFR (0.40) | TNFHDAC6 | |
| SCHEMBL2922474 | 0.80 | TNF (0.54) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL4381827 | 0.79 | HDAC6 (0.51) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL7210734 | 0.79 | HDAC6 (0.53) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL5562061 | 0.79 | HDAC6 (0.55) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL664005 | 0.79 | HDAC6 (0.55) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL7452317 | 0.78 | TNF (0.45) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL7211439 | 0.78 | HDAC6 (0.46) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL8585458 | 0.77 | ENPP1 (0.53) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |