Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.40 |
| ▸ | TNF | P01375 | 4/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789011 | 0.89 | TNF (0.48) | EGFRTNFHDAC6AURKAROCK2 | |
| SCHEMBL2947219 | 0.81 | EHMT2 (0.50) | TNFHDAC6KDR | |
| SCHEMBL4386072 | 0.81 | TNF (0.49) | EGFRTNFHDAC6SRCKDR | |
| SCHEMBL8525239 | 0.80 | TNF (0.44) | TNFHDAC6 | |
| SCHEMBL5216513 | 0.80 | HDAC6 (0.45) | EGFRTNFKITHDAC6KDR | |
| SCHEMBL7205402 | 0.79 | HDAC6 (0.51) | EGFRTNFHDAC6KDR | |
| SCHEMBL8526204 | 0.79 | EGFR (0.53) | EGFRKITAURKAAXLLCK | |
| SCHEMBL4381827 | 0.78 | HDAC6 (0.51) | TNFHDAC6ALDH1A1 | |
| SCHEMBL8525484 | 0.78 | KDM1A (0.46) | EGFRKITAURKAAXLSRC | |
| SCHEMBL7452615 | 0.78 | HDAC6 (0.50) | TNFHDAC6ALDH1A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |