Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.70 |
| ▸ | MMP2 | P08253 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 6/20 | 0.47 |
| ▸ | MMP1 | P03956 | 5/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP7 | P09237 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27432261 | 1.00 | MMP9 (0.70) | MMP9MMP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27476403 | 1.00 | MMP9 (0.70) | MMP9MMP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31630255 | 0.97 | MMP2 (0.74) | MMP9MMP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31630491 | 0.97 | MMP2 (0.74) | MMP9MMP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7308413 | 0.85 | MMP9 (0.95) | MMP9MMP2SMN1; SMN2MMP13MMP1 | |
| SCHEMBL7308416 | 0.85 | MMP9 (0.95) | MMP9MMP2SMN1; SMN2MMP13MMP1 | |
| SCHEMBL31630322 | 0.84 | MMP9 (0.76) | MMP9MMP2SMN1; SMN2MMP13MMP1 | |
| SCHEMBL31630207 | 0.84 | MMP2 (0.49) | MMP9MMP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31630110 | 0.84 | MMP2 (0.49) | MMP9MMP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27438204 | 0.83 | MMP9 (0.62) | MMP9MMP2SMN1; SMN2MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883131-A | Cyclic sulfone derivatives | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0818442-A2 | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor | PFIZER INC. (US) | 1998-01-14 | — | — | EP | disclosed |