Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | F12 | P00748 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895053 | 0.84 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL34473205 | 0.84 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| Formaldehyde SCHEMBL22343884 | 0.77 | PLAU (0.47) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL194555 | 0.76 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL291936 | 0.76 | CYP2A6 (0.55) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL25417027 | 0.76 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL3057928 | 0.76 | NCOA3 (0.51) | PLAUCYP2A6F12NCF1NOS3 | |
| Hydrochloric Acid SCHEMBL27892483 | 0.74 | PLAU (0.48) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL27667635 | 0.74 | PLAU (0.48) | PLAUCYP2A6F12NCF1NOS3 | |
| Quinoline SCHEMBL28260654 | 0.74 | ALDH1A1 (0.55) | PLAUCYP2A6F12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916891-A | CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-29 | — | — | US | claimed |