Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.43 |
| ▸ | BID | P55957 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489424 | 1.00 | THRA (0.59) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL8490567 | 1.00 | THRA (0.59) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL3226319 | 0.86 | THRA (0.56) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL3215293 | 0.86 | THRA (0.56) | THRATHRBLIPGALOX5PTGS2 | |
| Ethylene SCHEMBL2895477 | 0.85 | THRA (0.59) | THRATHRBLIPGALOX5PTGS2 | |
| Ethylene SCHEMBL2174988 | 0.85 | THRA (0.59) | THRATHRBLIPGALOX5PTGS2 | |
| Ethylene SCHEMBL4621010 | 0.85 | THRA (0.59) | THRATHRBLIPGALOX5PTGS2 | |
| Ethylene SCHEMBL1896180 | 0.85 | THRA (0.59) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL9505410 | 0.85 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 | |
| SCHEMBL941553 | 0.85 | THRA (0.58) | THRATHRBLIPGALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999014204-A1 | SUBSTITUTED 1,2,4-TRIAZOLES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | G.D. SEARLE & CO. (US) | 1999-03-25 | — | — | WO | disclosed |