Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.52 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.32 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexanone SCHEMBL29234655 | 0.80 | TRIM24 (0.58) | TRIM24TRIM33ALDH1A1 | |
| Tromethamine SCHEMBL9780974 | 0.79 | MEN1 (0.77) | MEN1LMNAKMT2AS1PR1TNNC1 | |
| Cyclohexanone SCHEMBL28169268 | 0.76 | TRIM24 (0.69) | TRIM24TRIM33ALDH1A1LMNA | |
| Cyclohexanone SCHEMBL28351148 | 0.76 | TRIM24 (0.69) | TRIM24TRIM33ALDH1A1LMNA | |
| Cyclohexanone SCHEMBL5010013 | 0.76 | TRIM24 (0.69) | TRIM24TRIM33ALDH1A1LMNA | |
| Cycloheptanone SCHEMBL28843909 | 0.76 | TRIM24 (0.69) | TRIM24TRIM33ALDH1A1LMNA | |
| Tromethamine SCHEMBL28812623 | 0.76 | MEN1 (0.48) | MEN1LMNAKMT2AS1PR1TNNC1 | |
| Hydroxyamine SCHEMBL28799169 | 0.76 | TRIM24 (0.79) | TRIM24TRIM33ALDH1A1KMT2A | |
| Cyclohexanone SCHEMBL11786724 | 0.76 | — | — | |
| Cyclohexanone SCHEMBL28210843 | 0.75 | TRIM24 (0.58) | TRIM24TRIM33ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941295-A1 | METHOD FOR COATING SUBSTRATES, PREFERABLY WITH METAL | BASF Coatings AG (DE) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998024857-A1 | METHOD FOR COATING SUBSTRATES, PREFERABLY WITH METAL | BASF COATINGS AG (DE) | 1998-06-11 | — | — | WO | disclosed |
| US-5427661-A | Containing homopolymer of alkyl vinyl ether to prevent defects ; automobile primers | BASF LACKE & FARBEN AKTIENGESELLSCHAFT (DE) | 1995-06-27 | — | — | US | disclosed |
| EP-0386132-A1 | PROCESS FOR COATING ELECTRICALLY CONDUCTIVE SUSBTRATES, SUBSTRATES SO OBTAINED, AND AQUEOUS ELECTROPHORETIC ENAMELLING BATHS | BASF Lacke + Farben AG (DE) | 1990-09-12 | — | — | EP | disclosed |
| WO-1989006672-A1 | PROCESS FOR COATING ELECTRICALLY CONDUCTIVE SUSBTRATES, SUBSTRATES SO OBTAINED, AND AQUEOUS ELECTROPHORETIC ENAMELLING BATHS | BASF LACKE + FARBEN AKTIENGESELLSCHAFT (DE) | 1989-07-27 | — | — | WO | disclosed |
| EP-0324950-A1 | Process for coating electrically conductive substrates, accordingly coated substrates and aqueous electrodeposition baths | BASF Lacke + Farben AG (DE) | 1989-07-26 | — | — | EP | disclosed |