Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 8/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205019 | 0.90 | CHEK1 (0.58) | CHEK1SRCEGFRKDRAURKA | |
| SCHEMBL7211414 | 0.90 | CHEK1 (0.58) | CHEK1SRCEGFRKDRAURKA | |
| Hydrochloric Acid SCHEMBL7211395 | 0.89 | CHEK1 (0.57) | CHEK1SRCEGFRKDRAURKA | |
| SCHEMBL7206149 | 0.83 | EHMT2 (0.52) | CHEK1SRCEGFRKDRKIT | |
| Hydrochloric Acid SCHEMBL7205559 | 0.82 | EHMT2 (0.52) | CHEK1SRCEGFRKDRKIT | |
| Hydrochloric Acid SCHEMBL8525709 | 0.82 | CHEK1 (0.50) | CHEK1SRCEGFRKDRKIT | |
| SCHEMBL7210071 | 0.81 | CHEK1 (0.52) | CHEK1SRCEGFRKDRKIT | |
| SCHEMBL7211365 | 0.81 | CHEK1 (0.52) | CHEK1SRCEGFRKDRKIT | |
| SCHEMBL8525237 | 0.81 | MEN1 (0.39) | CHEK1SRCEGFRKDRAURKA | |
| Hydrochloric Acid SCHEMBL7205688 | 0.81 | CHEK1 (0.52) | CHEK1SRCEGFRKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |