Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 6/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8525056 | 0.99 | MEN1 (0.38) | MEN1KMT2AEGFRKDRCHEK1 | |
| SCHEMBL8525577 | 0.81 | CHEK1 (0.50) | EGFRKDRCHEK1ATMSRC | |
| SCHEMBL7205793 | 0.79 | KDR (0.48) | KDR | |
| SCHEMBL7205653 | 0.79 | PDE4A (0.45) | EGFRKDRTNKSPARP1TNKS2 | |
| SCHEMBL8585458 | 0.78 | ENPP1 (0.53) | MEN1KMT2AEGFRKDRENPP1 | |
| SCHEMBL7209523 | 0.78 | KDR (0.49) | EGFRKDRATMEPHA2AURKA | |
| SCHEMBL7211473 | 0.77 | EGFR (0.49) | EGFRKDRTNKSPARP1TNKS2 | |
| SCHEMBL7206414 | 0.77 | KDR (0.46) | KDR | |
| Hydrochloric Acid SCHEMBL7209557 | 0.77 | KDR (0.48) | EGFRKDRATMEPHA2AURKA | |
| SCHEMBL7206149 | 0.77 | EHMT2 (0.52) | EGFRKDRCHEK1ERBB2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |