Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920989 | 0.78 | ACHE (0.43) | BRD4CREBBPTSHREP300PNMT | |
| SCHEMBL21782466 | 0.78 | ACHE (0.43) | BRD4CREBBPTSHREP300PNMT | |
| SCHEMBL2997969 | 0.76 | ACHE (0.44) | BRD4CREBBPTSHREP300PNMT | |
| SCHEMBL94115 | 0.76 | ESR2 (0.49) | BRD4CREBBPTSHREP300LMNA | |
| SCHEMBL7897325 | 0.76 | CMA1 (0.43) | BRD4CREBBPTSHREP300ADRA2A | |
| SCHEMBL7037554 | 0.76 | MAPT (0.42) | BRD4CREBBPTSHREP300PNMT | |
| SCHEMBL12965849 | 0.75 | AR (0.45) | BRD4CREBBPTSHREP300PNMT | |
| SCHEMBL12965982 | 0.73 | AR (0.44) | BRD4CREBBPTSHREP300PNMT | |
| SCHEMBL13799420 | 0.73 | ACHE (0.47) | — | |
| SCHEMBL9972552 | 0.73 | PARP1 (0.38) | BRD4CREBBPTSHREP300PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083170-A1 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-06-21 | — | — | WO | disclosed |
| EP-2455376-A1 | Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2010144646-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | WO | disclosed |
| WO-2010120935-A1 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2010-10-21 | — | — | WO | disclosed |